Formulation and Evaluation of Oro-dispersible Bromhexine Hydrochloride Granules Using Sachelac-80

Background: Patients with sudden episodes of allergic or epileptic attacks and those who are mentally ill less non-compliant there is a lack effective therapy. The need for delivering therapy at very fast pace the primary objective. Though oral medications exist such patients these have their own disadvantages. Methods: Wet granulation method was used preparation Orodispersible (ORD) granules using Pearlitol 200 SD Sachelac 80. Water soluble Bromhexine HCl were prepared by incorporating suitable surfactants, binder, to some extent co-surfactant oils as well, so increase its bioavailability. characterized standard methods. Results: FTIR studies show drug- excipient compatibility. Formulation F1 shows superior results than other batches. Drug content 97.5 %, excellent flow properties drug release 102.3 % observed F1. A temperature 40 ± 2°C relative humidity 75 5% RH, found be most stable formulation it indicated no significant changes in any parameters mainly content. Similarly, study suggests compatibility interaction between excipients well active ingredient. Conclusion: This showed that resulted pharmaceutical had onset action, enhanced bioavailability, compliance patients, stability cost effective.